Summary

• Promotes cardiovascular health, including support for dyslipidemia and elevated LDL-C
• Provides the stable and bioavailable form of vitamin B5, necessary for the biosynthesis of coenzyme A
• Coenzyme A is needed for multiple cellular effects, including energy production and fatty acid synthesis
• Combined in an antioxidant formula, complexed with organic vegetables, berries, and anti-inflammatory botanicals 450 mg per serving allows for dosing used in clinical trials

Indications

• Promotes cardiovascular health, including support for dyslipidemia and elevated LDL-C
• Provides the stable and bioavailable form of vitamin B5, necessary for the biosynthesis of coenzyme A
• Coenzyme A is needed for multiple cellular effects, including energy production and fatty acid synthesis
• Combined in an antioxidant formula, complexed with organic vegetables, berries, and anti-inflammatory botanicals 450 mg per serving allows for dosing used in clinical trials

Ingredients

Each Softgel Contains:
D-Pantethine : 450 mg

Softgel (gelatin, glycerin, purified water).

Description

Pantethine is a stable and bioavailable form of vitamin B5 (pantothenic acid), well-recognized for its favourable effects on markers of cardiovascular disease.
1
After initial conversion to pantetheine (two molecules of pantethine linked by a disulfide bridge) by intestinal bacteria, it is ultimately used for the biosynthesis of coenzyme A (CoA). CoA is a carrier of acetyl groups critical to multiple metabolic processes within the cell, including the Krebs (citric acid) cycle, as well as fatty acid and phospholipid metabolism.
1
Pantethine is commonly referred to as the “anti-stress vitamin” because of its broad utility for a wide range of processes, including energy production, cellular signalling, and the regulation of inflammation and immune function.
2


Case-control analysis indicates that higher pantothenic acid levels are associated with a lower risk of coronary heart disease, likely mediated via several mechanisms.
3
Greater intake has been associated with lower C-reactive protein levels, a marker for inflammation.
4,5
Controlled trials with participants at moderate risk of cardiovascular disease, with no inhibition of CoQ10 synthesis, showed that pantethine specifically improves dyslipidemia, including reducing non-HDL-C, triglycerides, and resulting in as much as an 11% decrease in LDL-C (vs. 3% increase with the placebo).6–8 Additionally, pantethine provides protection against LDL-C peroxidation, an independent risk factor for atherosclerotic cardiovascular disease. A vitamin B5 deficiency has been associated with hypertension, likely because of its requirement for adrenal function.
9–12

Quantity

60 Softgels

Dose

Recommended Adult Dose: 1 softgel 2 times per day with food or as directed by a health care practitioner. For use beyond 4 months, consult a health care practitioner.

References

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2026